Treatment with resveratrol attenuates sublesional bone loss in spinal cord-injured rats.

ABSTRACT:

Background and purpose

Sublesional osteoporosis predisposes individuals with spinal cord injury (SCI) to an increased risk of low-trauma fracture. The aim of the present work was to investigate the effect of treatment with resveratrol (RES) on sublesional bone loss in spinal cord-injured rats.

Experimental approach

Complete SCI was generated by surgical transaction of the cord at the T10-12 level. Treatment with RES (400 mg·kg(-1) body mass per day(-1) , intragastrically) was initiated 12 h after the surgery for 10 days. Then, blood was collected and femurs and tibiae were removed for evaluation of the effects of RES on bone tissue after SCI.

Key results

Treatment of SCI rats with RES prevented the reduction of bone mass including bone mineral content and bone mineral

SUBMITTER: Wang HD 

PROVIDER: S-EPMC3799594 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature