Measles contributes to rheumatoid arthritis: evidence from pathway and network analyses of genome-wide association studies.

ABSTRACT: Growing evidence from epidemiological studies indicates the association between rheumatoid arthritis (RA) and measles. However, the exact mechanism for this association is still unclear now. We consider that the strong association between both diseases may be caused by shared genetic pathways. We performed a pathway analysis of large-scale RA genome-wide association studies (GWAS) dataset with 5,539 cases and 20,169 controls of European descent. Meanwhile, we evaluated our findings using previously identified RA loci, protein-protein interaction network and previous results from pathway analysis of RA and other autoimmune diseases GWAS. We confirmed four pathways including Cytokine-cytokine receptor interaction, Jak-STAT signaling, T cell receptor signaling and Cell adhesion molecules. Mea

SUBMITTER: Liu G 

PROVIDER: S-EPMC3799991 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature