Dataset Information

Afghan Hindu Kush: where Eurasian sub-continent gene flows converge.

ABSTRACT: Despite being located at the crossroads of Asia, genetics of the Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset of our samples, mitochondrial and Y- chromosome data from over 500 Afghan samples among these 5 ethnic groups. This Afghan data was supplemented with the same Y-chromosome analyses of samples from Iran, Kyrgyzstan, Mongolia and updated Pakistani samples (HGDP-CEPH). The data presented here was integrated into existing knowledge of pan-Eurasian genetic diversity. The pattern of genetic variation, revealed by structure-like and Principal Component analyses and Analysis of Molecular Variance indicates that the people of Afghanistan are made up of a mosaic of components representing various geographic regions of Eurasian ancestry. The absence of a major Central Asian-specific component indicates that the Hindu Kush, like the gene pool of Central Asian populations in general, is a confluence of gene flows rather than a source of distinctly autochthonous populations that have arisen in situ: a conclusion that is reinforced by the phylogeography of both haploid loci.

SUBMITTER: Di Cristofaro J

PROVIDER: S-EPMC3799995 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Afghan Hindu Kush: where Eurasian sub-continent gene flows converge.

Di Cristofaro Julie J Pennarun Erwan E Mazières Stéphane S Myres Natalie M NM Lin Alice A AA Temori Shah Aga SA Metspalu Mait M Metspalu Ene E Witzel Michael M King Roy J RJ Underhill Peter A PA Villems Richard R Chiaroni Jacques J

PloS one 20131018 10

Despite being located at the crossroads of Asia, genetics of the Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset of our samples, mitochondrial and Y- chromosome data from over 500 Afghan samples among these 5 ethnic groups. This Afghan data was supplemented with the same Y-chromosome analyses of samples from Iran, Kyrgyzstan, Mongolia and updated Pa ...[more]

PMID: 24204668

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Dataset Information

Afghan Hindu Kush: where Eurasian sub-continent gene flows converge.

Publications

Afghan Hindu Kush: where Eurasian sub-continent gene flows converge.

Similar Datasets

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