Neuraxial anesthesia decreases postoperative systemic infection risk compared with general anesthesia in knee arthroplasty.

ABSTRACT:

Background

Surgical stress has been shown to result in immune disturbance. Neuraxial anesthesia (NA) has long been hypothesized to blunt undesired surgical insults and thus limit immune compromise and improve surgical outcomes. We hypothesized that NA would decrease postoperative infectious complications compared with general anesthesia (GA) among knee arthroplasty patients.

Methods

We studied the American College of Surgeons National Surgical Quality Improvement Program database from 2005 to 2010. There were 16,555 patients included in our final cohort, with 9167 patients receiving GA and 7388 patients receiving spinal or epidural anesthesia.. Outcomes of interest included infection-related 30-day postoperative complications, including surgical site-related infections, pneu

SUBMITTER: Liu J 

PROVIDER: S-EPMC3800057 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature