Fenofibrate lowers blood pressure in salt-sensitive but not salt-resistant hypertension.

ABSTRACT:

Objective

Peroxisome proliferator-activated receptor α agonists reduce blood pressure in rodents, but clinical trials provide conflicting data regarding their effects in humans. We tested the hypothesis that the effect of fenofibrate on blood pressure depends on salt sensitivity.

Methods

Thirty-one hypertensive volunteers (17 salt-resistant, 14 salt-sensitive) completed a randomized, crossover, double-blind protocol with three dietary phases: low salt diet (10 mmol/day) followed by two consecutive high salt diets (200 mmol/day), each for 6 days. During high salt, volunteers were randomized to fenofibrate 160 mg/day or placebo. Hemodynamic and metabolic parameters were measured on the last morning of each treatment arm.

Results

Fenofibrate reduced triglycerides similar

SUBMITTER: Gilbert K 

PROVIDER: S-EPMC3800119 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature