HIV disease progression in the first year after delivery among African women followed in the HPTN 046 clinical trial.

ABSTRACT:

Background

Starting lifelong antiretroviral therapy (ART) in HIV-infected pregnant women may decrease HIV progression and transmission, but adherence after delivery may be difficult, especially for asymptomatic women. We evaluated disease progression among HIV-infected women not on ART with CD4⁺ lymphocyte counts above 200 cells per microliter at delivery.

Methods

We analyzed risk of death, progression to AIDS (stage IV or CD4 < 200 cells per microliter), or to CD4⁺ count <350 1 year after delivery among postpartum women enrolled to a prevention of breastfeeding transmission trial using the Kaplan-Meier method. In the primary analysis, women were censored if ART was initiated.

Results

Among 1285 women who were not WHO stage IV or less at 6 weeks postpartum, 49 (4.3%)

SUBMITTER: Watts DH 

PROVIDER: S-EPMC3800257 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature