Candidate gene associations with withdrawn behavior.

ABSTRACT:

Background

Social withdrawal is a core neuropsychiatric phenomenon in developmental psychopathology. Its presence predicts psychopathology across many domains, including depression, psychosis, autism, anxiety, and suicide. Withdrawn behavior is highly heritable, persistent, and characteristically worsens without intervention. To date, few studies have successfully identified genetic associations with withdrawn behavior, despite the abundance of evidence of its heritability. This may be due to reliance of categorical over dimensional measures of the behaviorally inhibited phenotype. The aim of this study is to identify associations between known psychiatric candidate genes and a dimensionally derived measure of withdrawn behavior.

Methods

Genetic information was collected on

SUBMITTER: Rubin DH 

PROVIDER: S-EPMC3800258 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature