Construction of a spirooxindole amide library through nitrile hydrozirconation-acylation-cyclization cascade.

ABSTRACT: A library of spirooxindoles containing varied elements of structural and stereochemical diversity has been constructed via a three step, one pot nitrile hydrozirconation-acylation-cyclization reaction sequence from common acyclic indole intermediates. The resulting library was evaluated for novelty through comparison with MLSMR and Maybridge compound collections.

SUBMITTER: LaPorte MG 

PROVIDER: S-EPMC3800499 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature