Multiplexed imaging of nanoparticles in tissues using laser desorption/ionization mass spectrometry.

ABSTRACT: Imaging of nanomaterials in biological tissues provides vital information for the development of nanotherapeutics and diagnostics. Multiplexed imaging of different nanoparticles (NPs) greatly reduces costs, the need to use multiple animals, and increases the biodistribution information that can enhance diagnostic applications and accelerate the screening of potential therapeutics. Various approaches have been developed for imaging NPs; however, the readout of existing imaging techniques relies on specific properties of the core material or surface ligands, and these techniques are limited because of the relatively small number of NPs that can be simultaneously measured in a single experiment. Here, we demonstrate the use of laser desorption/ionization mass spectrometry (LDI-MS) in an imagi

SUBMITTER: Yan B 

PROVIDER: S-EPMC3801209 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature