Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype.

ABSTRACT:

Unlabelled

Several factors have to be considered for implementing an accurate attenuation-correction (AC) method in a combined MR-PET scanner. In this work, some of these challenges were investigated, and an AC method based entirely on the MRI data obtained with a single dedicated sequence was developed and used for neurologic studies performed with the MR-PET human brain scanner prototype.

Methods

The focus was on the problem of bone-air segmentation, selection of the linear attenuation coefficient for bone, and positioning of the radiofrequency coil. The impact of these factors on PET data quantification was studied in simulations and experimental measurements performed on the combined MR-PET scanner. A novel dual-echo ultrashort echo time (DUTE) MRI sequence was proposed

SUBMITTER: Catana C 

PROVIDER: S-EPMC3801218 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature