Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step.

ABSTRACT: Long non-coding RNAs (lncRNAs) are a novel class of regulatory genes that play critical roles in various processes ranging from normal development to human diseases such as cancer progression. Recent studies have shown that lncRNAs regulate the gene expression by chromatin remodelling, transcription, splicing and RNA decay control, enhancer function, and epigenetic regulation. However, little is known about translation regulation by lncRNAs. We identified a translational regulatory lncRNA (treRNA) through genome-wide computational analysis. We found that treRNA is upregulated in paired clinical breast cancer primary and lymph-node metastasis samples, and that its expression stimulates tumour invasion in vitro and metastasis in vivo. Interestingly, we found that treRNA downregulates the exp

SUBMITTER: Gumireddy K 

PROVIDER: S-EPMC3801433 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature