Long-term exposure to PM10 and NO2 in association with lung volume and airway resistance in the MAAS birth cohort.

ABSTRACT:

Background

Findings from previous studies on the effects of air pollution exposure on lung function during childhood have been inconsistent. A common limitation has been the quality of exposure data used, and few studies have modeled exposure longitudinally throughout early life.

Objectives

We sought to study the long-term effects of exposure to particulate matter with an aerodynamic diameter ≤ 10 μm (PM10) and to nitrogen dioxide (NO2) on specific airway resistance (sR(aw)) and forced expiratory volume in 1 sec (FEV1) before and after bronchodilator treatment. Subjects were from the Manchester Asthma and Allergy Study (MAAS) birth cohort (n = 1,185).

Methods

Spirometry was performed during clinic visits at ages 3, 5, 8, and 11 years. Individual-level PM10 and NO2 exp

SUBMITTER: Molter A 

PROVIDER: S-EPMC3801452 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature