Body mass index predicts insulin resistance in survivors of pediatric acute lymphoblastic leukemia.

ABSTRACT:

Background

Pediatric acute lymphoblastic leukemia (ALL) therapies have been associated with many late effects, including obesity, hyperglycemia, and insulin resistance. Few data are available linking these abnormalities to specific risk factors present during ALL treatment.

Methods

Retrospective cohort study with prospective follow-up. Subjects had been diagnosed with ALL at ages 1-18 years and had been off chemotherapy for >9 months. Oral glucose tolerance testing (OGTT) was performed and these results compared to demographic, treatment, and anthropomorphic data from medical records.

Results

Twenty-seven subjects (11 female) were evaluated. Mean (+/-SD) diagnosis age 5.7 +/- 3.5 years, mean study age 11.3 +/- 3.7 years, mean time off therapy 2.8 +/- 1.5 years. Six su

SUBMITTER: Lowas S 

PROVIDER: S-EPMC3804011 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature