Transcriptional profiling of mEq-dependent genes in Marek's disease resistant and susceptible inbred chicken lines.

ABSTRACT: Marek's disease (MD) is an economically significant disease in chickens caused by the highly oncogenic Marek's disease virus (MDV). Understanding the genes and biological pathways that confer MD genetic resistance should lead towards the development of more disease resistant commercial poultry flocks or improved MD vaccines. MDV mEq, a bZIP transcription factor, is largely attributed to viral oncogenicity though only a few host target genes have been described, which has impeded our understanding of MDV-induced tumorigenesis. Given the importance of mEq in MDV-induced pathogenesis, we explored the role of mEq in genetic resistance to MDV. Using global transcriptome analysis and cells from MD resistant or susceptible birds, we compared the response to infection with either wild type MDV or

SUBMITTER: Subramaniam S 

PROVIDER: S-EPMC3804455 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature