Development of scoring functions for antibody sequence assessment and optimization.

ABSTRACT: Antibody development is still associated with substantial risks and difficulties as single mutations can radically change molecule properties like thermodynamic stability, solubility or viscosity. Since antibody generation methodologies cannot select and optimize for molecule properties which are important for biotechnological applications, careful sequence analysis and optimization is necessary to develop antibodies that fulfil the ambitious requirements of future drugs. While efforts to grab the physical principles of undesired molecule properties from the very bottom are becoming increasingly powerful, the wealth of publically available antibody sequences provides an alternative way to develop early assessment strategies for antibodies using a statistical approach which is the objective

SUBMITTER: Seeliger D 

PROVIDER: S-EPMC3804498 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature