Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population.

ABSTRACT:

Purpose

Polymorphisms in the insulin-like growth factor 1 (IGF1) gene were previously associated with high or extreme myopia in Caucasian and Chinese populations. In the present study, we investigated whether IGF1 polymorphisms are associated with high myopia in a Japanese population.

Methods

A total of 446 Japanese patients with high myopia (≤-9.00 diopters) and 481 Japanese healthy controls (+1.50 diopters to -1.50 diopters) were recruited. We genotyped seven tagging single-nucleotide polymorphisms (SNPs) in IGF1 and assessed allelic and haplotypic diversity in cases and controls.

Results

There were no statistically significant differences in the allele frequencies of IGF1 SNPs and genotypes between cases and controls (P>0.05). However, the A allele of rs5742629 and

SUBMITTER: Yoshida M 

PROVIDER: S-EPMC3804590 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature