Relation between volume of exercise and clinical outcomes in patients with heart failure.

ABSTRACT:

Objectives

This study determined whether greater volumes of exercise were associated with greater reductions in clinical events.

Background

The HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial showed that among patients with heart failure (HF), regular exercise confers a modest reduction in the adjusted risk for all-cause mortality or hospitalization.

Methods

Patients randomized to the exercise training arm of HF-ACTION who were event-free at 3 months after randomization were included (n = 959). Median follow-up was 28.2 months. Clinical endpoints were all-cause mortality or hospitalization and cardiovascular mortality or HF hospitalization.

Results

A reverse J-shaped association was observed between exercise volum

SUBMITTER: Keteyian SJ 

PROVIDER: S-EPMC3804919 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature