Renal clearance and intestinal generation of p-cresyl sulfate and indoxyl sulfate in CKD.

ABSTRACT:

Background and objectives

p-Cresyl sulfate and indoxyl sulfate contribute to cardiovascular disease and progression of renal disease. Renal clearance of both solutes mainly depends on tubular secretion, and serum concentrations are widely dispersed for any given stage of CKD. From this information, it is inferred that estimated GFR is not a suitable proxy of the clearance of these solutes. Formal clearance studies have, however, not been performed to date.

Design, setting, participants, & measurements

This study analyzed renal clearances of p-cresyl sulfate and indoxyl sulfate in the Leuven CKD cohort (NCT00441623; inclusion between November of 2005 and September of 2006) and explored their relationship with estimated GFR. Multivariate linear regression models were built to

SUBMITTER: Poesen R 

PROVIDER: S-EPMC3805062 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature