Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years.

ABSTRACT:

Objectives

To determine whether maternal obesity during pregnancy is associated with increased mortality from cardiovascular events in adult offspring.

Design

Record linkage cohort analysis.

Setting

Birth records from the Aberdeen Maternity and Neonatal databank linked to the General Register of Deaths, Scotland, and the Scottish Morbidity Record systems.

Population

37 709 people with birth records from 1950 to present day.

Main outcome measures

Death and hospital admissions for cardiovascular events up to 1 January 2012 in offspring aged 34-61. Maternal body mass index (BMI) was calculated from height and weight measured at the first antenatal visit. The effect of maternal obesity on outcomes in offspring was tested with time to event analysis with Cox

SUBMITTER: Reynolds RM 

PROVIDER: S-EPMC3805484 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature