Colitis promotes adaptation of an intestinal nematode: a Heligmosomoides polygyrus mouse model system.

ABSTRACT: The precise mechanism of the very effective therapeutic effect of gastrointestinal nematodes on some autoimmune diseases is not clearly understood and is currently being intensively investigated. Treatment with living helminths has been initiated to reverse intestinal immune-mediated diseases in humans. However, little attention has been paid to the phenotype of nematodes in the IBD-affected gut and the consequences of nematode adaptation. In the present study, exposure of Heligmosomoides polygyrus larvae to the changed cytokine milieu of the intestine during colitis reduced inflammation in an experimental model of dextran sulphate sodium (DSS)- induced colitis, but increased nematode establishment in the moderate-responder BALB/c mouse strain. We used mass spectrometry in combination with

SUBMITTER: Donskow-Lysoniewska K 

PROVIDER: S-EPMC3805612 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature