Bone morphogenetic protein 6 expression in oral cavity squamous cell cancer is associated with bone invasion.

ABSTRACT:

Objectives/hypothesis

To evaluate bone invasion, survival, and expression of bone morphogenetic protein-6 (BMP-6) in oral cavity cancer in the context of known biomarkers indicative of poor prognosis.

Study design

Molecular expression study combined with retrospective chart review of corresponding patients at a tertiary care center.

Methods

Between 2000 and 2009, a total of 197 patients underwent resection for oral cavity squamous cell carcinoma. Of these, 30 pathologic specimens were chosen for further molecular analysis. These 30 patients were separated into three groups (10 per group) based on American Joint Committee on Cancer (AJCC) staging and staging based on size alone (TAJCC /SIZE ). The first group consisted of tumors staged as T2 /2 based on size less than

SUBMITTER: Kejner AE 

PROVIDER: S-EPMC3805669 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature