Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.

ABSTRACT:

Background & aims

Cirrhosis and liver cancer are potential outcomes of advanced nonalcoholic fatty liver disease (NAFLD). It is not clear what factors determine whether patients will develop advanced or mild NAFLD, limiting noninvasive diagnosis and treatment before clinical sequelae emerge. We investigated whether DNA methylation profiles can distinguish patients with mild disease from those with advanced NAFLD, and how these patterns are functionally related to hepatic gene expression.

Methods

We collected frozen liver biopsies and clinical data from patients with biopsy-proven NAFLD (56 in the discovery cohort and 34 in the replication cohort). Samples were divided into groups based on histologic severity of fibrosis: F0-1 (mild) and F3-4 (advanced). DNA methylation profi

SUBMITTER: Murphy SK 

PROVIDER: S-EPMC3805742 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature