Structural optimization of Zn(II)-activated magnetic resonance imaging probes.

ABSTRACT: We report the structural optimization and mechanistic investigation of a series of bioactivated magnetic resonance imaging contrast agents that transform from low relaxivity to high relaxivity in the presence of Zn(II). The change in relaxivity results from a structural transformation of the complex that alters the coordination environment about the Gd(III) center. Here, we have performed a series of systematic modifications to determine the structure that provides the optimal change in relaxivity in response to the presence of Zn(II). Relaxivity measurements in the presence and absence of Zn(II) were used in conjunction with measurements regarding water access (namely, number of water molecules bound) to the Gd(III) center and temperature-dependent (13)C NMR spectroscopy to determine how

SUBMITTER: Matosziuk LM 

PROVIDER: S-EPMC3805786 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature