Epigenetic regulation of axon outgrowth and regeneration in CNS injury: the first steps forward.

ABSTRACT: Inadequate axonal sprouting and lack of regeneration limit functional recovery following neurologic injury, such as stroke, brain, and traumatic spinal cord injury. Recently, the enhancement of the neuronal regenerative program has led to promising improvements in axonal sprouting and regeneration in animal models of axonal injury. However, precise knowledge of the essential molecular determinants of this regenerative program remains elusive, thus limiting the choice of fully effective therapeutic strategies. Given that molecular regulation of axonal outgrowth and regeneration requires carefully orchestrated waves of gene expression, both temporally and spatially, epigenetic changes may be an ideal regulatory mechanism to address this unique need. While recent evidence suggests that epigen

SUBMITTER: Lindner R 

PROVIDER: S-EPMC3805867 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature