PBMC transcription profiles of pigs with divergent humoral immune responses and lean growth performance.

ABSTRACT:

Background

The identification of key genes and regulatory networks in the transcriptomic responses of blood cells to antigen stimulation could facilitate the understanding of host defence and disease resistance. Moreover, genetic relationships between immunocompetence and the expression of other phenotypes, such as those of metabolic interest, are debated but incompletely understood in farm animals. Both positive and negative associations between immune responsiveness and performance traits such as weight gain or lean growth have been reported. We designed an in vivo microarray study of transcriptional changes in porcine peripheral blood mononuclear cells (PBMCs) during the immune response to tetanus toxoid (TT) as a model antigen for combined cellular (Th1) and humoral (Th2) respo

SUBMITTER: Adler M 

PROVIDER: S-EPMC3805897 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature