Depressive symptom severity is related to poorer cognitive performance in prodromal Huntington disease.

ABSTRACT:

Objective

Depression is associated with more severe cognitive deficits in many neurological disorders, though the investigation of this relationship in Huntington disease (HD) has been limited. This study examined the relationship between depressive symptom severity and measures of executive functioning, learning/memory, and attention in prodromal HD.

Method

Participants (814 prodromal HD, 230 gene-negative) completed a neuropsychological test battery and the Beck Depression Inventory-II (BDI-II). Based on the BDI-II, there were 637 participants with minimal depression, 89 with mild depression, 61 with moderate depression, and 27 with severe depression in the prodromal HD group.

Results

ANCOVA (controlling for age, sex, and education) revealed that performance on SDMT

SUBMITTER: Smith MM 

PROVIDER: S-EPMC3806339 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature