Potential pharmacokinetic role of organic cation transporters in modulating the transcorneal penetration of its substrates administered topically.

ABSTRACT:

Purpose

We hypothesize organic cation transporters (OCT) may have a potential role in determining the pharmacokinetics and toxicity of organic cation drugs applied topically. Hence, in the present in vivo study, we attempted to evaluate the role of OCT in modulating the transport of its substrates after topical application.

Methods

New Zealand albino rabbits of either sex were used. Transcorneal penetration of OCT substrates tetraethylammonium and metformin after single instillation was evaluated in the absence and presence of OCT blockers (quinidine and atropine). Aqueous humor (AH) samples were collected through paracentesis amounting to 70-100 μl under topical anesthesia at various time intervals. The samples were subjected for estimation of both substrate as well as bloc

SUBMITTER: Nirmal J 

PROVIDER: S-EPMC3806579 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature