The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study.

ABSTRACT:

Objective

To assess regional patterns of gray and white matter atrophy in familial Alzheimer disease (FAD) mutation carriers.

Methods

A total of 192 participants with volumetric T1-weighted MRI, genotyping, and clinical diagnosis were available from the Dominantly Inherited Alzheimer Network. Of these, 69 were presymptomatic mutation carriers, 50 were symptomatic carriers (31 with Clinical Dementia Rating [CDR] = 0.5, 19 with CDR > 0.5), and 73 were noncarriers from the same families. Voxel-based morphometry was used to identify cross-sectional group differences in gray matter and white matter volume.

Results

Significant differences in gray matter (p < 0.05, family-wise error-corrected) were observed between noncarriers and mildly symptomatic (CDR = 0.5) carriers in t

SUBMITTER: Cash DM 

PROVIDER: S-EPMC3806583 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature