Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents.

ABSTRACT:

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DNA repair competency is one determinant of sensitivity to certain chemotherapy drugs, such as cisplatin. Cancer cells with intact DNA repair can avoid the accumulation of genome damage during growth and also can repair platinum-induced DNA damage. We sought genomic signatures indicative of defective DNA repair in cell lines and tumors and correlated these signatures to platinum sensitivity. The number of subchromosomal regions with allelic imbalance extending to the telomere (N(tAI)) predicted cisplatin sensitivity in vitro and pathologic response to preoperative cisplatin treatment in patients with triple-negative breast cancer (TNBC). In serous ovarian cancer treated with platinum-based chemotherapy, higher levels of N(tAI) forecast a better initial response. We found

SUBMITTER: Birkbak NJ 

PROVIDER: S-EPMC3806629 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature