Validity of sealant retention as surrogate for caries prevention--a systematic review.

ABSTRACT:

Introduction/aim

To appraise the clinical literature in determining whether loss of complete sealant retention as surrogate endpoint is directly associated with caries occurrence on sealed teeth as its clinical endpoint and to apply the appraised evidence in testing the null-hypothesis that the retention/caries ratio between different types of sealant materials (resin and glass-ionomer cement) is not statistically significant (= Prentice criterion for surrogate endpoint validity).

Methods

Databases searched PubMed/Medline, Directory of Open Access Journals; IndMed, Scielo. Systematic reviews were checked for suitable trials. The search terms: "fiss* AND seal*" and "fissure AND sealant" were used. Article selection criteria were: clinical trial reporting on the retention and

SUBMITTER: Mickenautsch S 

PROVIDER: S-EPMC3806731 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature