The immunological and virological consequences of planned treatment interruptions in children with HIV infection.

ABSTRACT:

Objectives

To evaluate the immunological and viral consequences of planned treatment interruptions (PTI) in children with HIV.

Design

This was an immunological and virological sub-study of the Paediatric European Network for Treatment of AIDS (PENTA) 11 trial, which compared CD4-guided PTI of antiretroviral therapy (ART) with continuous therapy (CT) in children.

Methods

HIV-1 RNA and lymphocyte subsets, including CD4 and CD8 cells, were quantified on fresh samples collected during the study; CD45RA, CD45RO and CD31 subpopulations were evaluated in some centres. For 36 (18 PTI, 18 CT) children, immunophenotyping was performed and cell-associated HIV-1 DNA analysed on stored samples to 48 weeks.

Results

In the PTI group, CD4 cell count fell rapidly in the first 1

SUBMITTER: Klein N 

PROVIDER: S-EPMC3806774 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature