Development and histopathological characterization of tumorgraft models of pancreatic ductal adenocarcinoma.

ABSTRACT: Pancreatic cancer is the one of the deadliest of all malignancies. The five year survival rate for patients with this disease is 3-5%. Thus, there is a compelling need for novel therapeutic strategies to improve the clinical outcome for patients with pancreatic cancer.  Several groups have demonstrated for other types of solid tumors that early passage human tumor xenograft models can be used to define some genetic and molecular characteristics of specific human tumors. Published studies also suggest that murine tumorgraft models (early passage xenografts derived from direct implantation of primary tumor specimens) may be useful in identifying compounds with efficacy against specific tumor types.  Because pancreatic cancer is a fatal disease and few well-characterized model systems are ava

SUBMITTER: Garcia PL 

PROVIDER: S-EPMC3806809 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature