Aβ-related angiitis: comparison with CAA without inflammation and primary CNS vasculitis.

ABSTRACT:

Objective

To analyze the clinical findings, response to therapy, and outcomes of patients with cerebral vascular amyloid-β (Aβ) deposition with and without inflammatory vascular infiltration.

Methods

We report 78 consecutive patients with cerebral vascular Aβ deposition examined at Mayo Clinic Rochester over 25 years (1987 through 2011). Specimens reviewed by a neuropathologist showed 40 with vascular Aβ peptide without inflammation (cerebral amyloid angiopathy [CAA]), 28 with granulomatous vasculitis (Aβ-related angiitis or ABRA), and 10 with perivascular CAA-related inflammation. We also matched findings in 118 consecutive patients with primary CNS vasculitis (PCNSV) without Aβ seen over 25 years (1983 through 2007).

Results

Compared to the 40 with CAA, the 28 with

SUBMITTER: Salvarani C 

PROVIDER: S-EPMC3806912 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature