MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1.

ABSTRACT: Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established (Oh et al., 2008). We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biological activity and the nature and position of substituents in these derived compounds.

SUBMITTER: Oh SJ 

PROVIDER: S-EPMC3807079 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature