Cognitive aging in persons with minimal amyloid-β and white matter hyperintensities.

ABSTRACT: Substantial individual differences exist in the magnitude of the cognitive decline associated with normal aging. Potential contributors to this intersubject variability include white matter hyperintensities (WMH) and preclinical Alzheimer's disease, evident as increased brain amyloid. This study examined whether older individuals with minimal evidence of WMH and/or brain amyloid-beta (seen on positron emission tomography with the Pittsburgh compound B radiotracer-PiB) still showed significant cognitive decrements compared to the young. Older individuals, conservatively screened for normal range performance on an extensive neuropsychological battery, underwent structural magnetic resonance imaging (MRI) and PiB scans and performed tests of information processing speed, working memory and in

SUBMITTER: Nebes RD 

PROVIDER: S-EPMC3807130 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature