Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys.

ABSTRACT: Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.

SUBMITTER: Ho C 

PROVIDER: S-EPMC3807282 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature