Signal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes.

ABSTRACT: Lytic activation of Epstein-Barr virus (EBV) is central to its life cycle and to most EBV-related diseases. However, not every EBV-infected B cell is susceptible to lytic activation. This lack of uniform susceptibility to lytic activation also directly impacts the success of viral oncolytic therapy for EBV cancers, yet determinants of susceptibility to lytic induction signals are not well understood. To determine if host factors influence susceptibility to EBV lytic activation, we developed a technique to separate lytic from refractory cells and reported that EBV lytic activation occurs preferentially in cells with lower levels of signal transducer and activator of transcription 3 (STAT3). Using this tool to detect single cells, we now extend the correlation between STAT3 and lytic versus

SUBMITTER: Hill ER 

PROVIDER: S-EPMC3807321 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature