Deciphering the interplay between two independent functions of the small RNA regulator SgrS in Salmonella.

ABSTRACT: Bacterial dual-function small RNAs regulate gene expression by RNA-RNA base pairing and also code for small proteins. SgrS is a dual-function small RNA in Escherichia coli and Salmonella that is expressed under stress conditions associated with accumulation of sugar-phosphates, and its activity is crucial for growth during stress. The base-pairing function of SgrS regulates a number of mRNA targets, resulting in reduced uptake and enhanced efflux of sugars. SgrS also encodes the SgrT protein, which reduces sugar uptake by a mechanism that is independent of base pairing. While SgrS base-pairing activity has been characterized in detail, little is known about how base pairing and translation of sgrT are coordinated. In the current study, we utilized a series of mutants to determine how trans

SUBMITTER: Balasubramanian D 

PROVIDER: S-EPMC3807431 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature