Evolutionary relationships among actinophages and a putative adaptation for growth in Streptomyces spp.

ABSTRACT: The genome sequences of eight Streptomyces phages are presented, four of which were isolated for this study. Phages R4, TG1, Hau3, and SV1 were isolated previously and have been exploited as tools for understanding and genetically manipulating Streptomyces spp. We also extracted five apparently intact prophages from recent Streptomyces spp. genome projects and, together with six phage genomes in the database, we analyzed all 19 Streptomyces phage genomes with a view to understanding their relationships to each other and to other actinophages, particularly the mycobacteriophages. Fifteen of the Streptomyces phages group into four clusters of related genomes. Although the R4-like phages do not share nucleotide sequence similarity with other phages, they clearly have common ancestry with clus

SUBMITTER: Smith MC 

PROVIDER: S-EPMC3807479 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature