Initial evidence that OPRM1 genotype moderates ventral and dorsal striatum functional connectivity during alcohol cues.

ABSTRACT:

Background

Endogenous opioids and striatal dopamine have been implicated in cue-induced alcohol craving and have been hypothesized to play a role in goal-directed, as opposed to habitual, alcohol use. This initial study examines dorsal and ventral striatal functional connectivity during alcohol-cue processing as a function of the A118G single-nucleotide polymorphism of the mu-opioid receptor (OPRM1) gene.

Methods

Seventeen individuals with alcohol dependence (6 females; 90% Caucasian; mean age = 29.4) underwent blood oxygen level-dependent functional magnetic resonance imaging, while performing an alcohol taste-cues task. Psychophysiological interaction analyses investigated associations of the OPRM1 genotype with ventral and dorsal striatum functional connectivity, using th

SUBMITTER: Ray LA 

PROVIDER: S-EPMC3808494 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature