Electrostatic origin of the unidirectionality of walking myosin V motors.

ABSTRACT: Understanding the basis for the action of myosin motors and related molecular machines requires a quantitative energy-based description of the overall functional cycle. Previous theoretical attempts to do so have provided interesting insights on parts of the cycle but could not generate a structure-based free energy landscape for the complete cycle of myosin. In particular, a nonphenomenological structure/energy-based understanding of the unidirectional motion is still missing. Here we use a coarse-grained model of myosin V and generate a structure-based free energy surface of the largest conformational change, namely the transition from the post- to prepowerstroke movement. We also couple the observed energetics of ligand binding/hydrolysis and product release to that of the conformationa

SUBMITTER: Mukherjee S 

PROVIDER: S-EPMC3808596 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature