Treatment of hospital-acquired pneumonia with linezolid or vancomycin: a systematic review and meta-analysis.

ABSTRACT:

Objective

Hospital-acquired pneumonia remains the most lethal and expensive nosocomial infection worldwide. Optimal therapy remains controversial. We aimed to compare mortality and clinical response outcomes in patients treated with either linezolid or vancomycin.

Design

Systematic review and meta-analysis.

Data sources

PubMed, EMBASE, Cochrane Library, American College of Physicians Journal Club, Evidence-based Medicine BMJ and abstracts from infectious diseases and critical care meetings were searched through April 2013.

Eligibility criteria for selecting studies

All randomised clinical trials comparing linezolid to vancomycin for hospital-acquired pneumonia.

Data extraction

Preferred reporting items for systematic reviews and meta-analyses guidelines

SUBMITTER: Kalil AC 

PROVIDER: S-EPMC3808765 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature