Mind the gap: difference between Framingham heart age and real age increases with age in HIV-positive individuals-a clinical cohort study.

ABSTRACT:

Objectives

To measure the excess risk of cardiovascular disease (CVD) in HIV-positive individuals by comparing 'heart age' with real age and to estimate associations of patients' characteristics with heart age deviation (heart age-real age).

Design

Clinical Cohort Study.

Setting

Bristol HIV clinic, Brecon Unit at Southmead Hospital, Bristol, UK.

Participants

749 HIV-positive adults who attended for care between 2008 and 2011. Median age was 42 years (IQR 35-49), 67% were male and 82% were treated with antiretroviral therapy.

Main outcome measures

We calculated the Framingham 10-year risk of CVD and traced back to 'heart age', the age of an individual with the same score but ideal risk factor values. We estimated the relationship between heart age deviati

SUBMITTER: Davies TL 

PROVIDER: S-EPMC3808785 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature