PRImary care Streptococcal Management (PRISM) study: identifying clinical variables associated with Lancefield group A β-haemolytic streptococci and Lancefield non-Group A streptococcal throat infections from two cohorts of patients presenting with an acute sore throat.

ABSTRACT:

Objective

To assess the association between features of acute sore throat and the growth of streptococci from culturing a throat swab.

Design

Diagnostic cohort.

Setting

UK general practices.

Participants

Patients aged 5 or over presenting with an acute sore throat. Patients were recruited for a second cohort (cohort 2, n=517) consecutively after the first (cohort 1, n=606) from similar practices.

Main outcome

Predictors of the presence of Lancefield A/C/G streptococci.

Results

The clinical score developed from cohort 1 had poor discrimination in cohort 2 (bootstrapped estimate of area under the receiver operator characteristic (ROC) curve (0.65), due to the poor validity of the individual items in the second data set. Variables significant in mult

SUBMITTER: Little P 

PROVIDER: S-EPMC3808825 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature