The ABC-type efflux pump MacAB protects Salmonella enterica serovar typhimurium from oxidative stress.

ABSTRACT:

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Multidrug efflux pumps are integral membrane proteins known to actively excrete antibiotics. The macrolide-specific pump MacAB, the only ABC-type drug efflux pump in Salmonella, has previously been linked to virulence in mice. The molecular mechanism of this link between macAB and infection is unclear. We demonstrate that macAB plays a role in the detoxification of reactive oxygen species (ROS), compounds that salmonellae are exposed to at various stages of infection. macAB is induced upon exposure to H2O2 and is critical for survival of Salmonella enterica serovar Typhimurium in the presence of peroxide. Furthermore, we determined that macAB is required for intracellular replication inside J774.A1 murine macrophages but is not required for survival in ROS-deficient J774

SUBMITTER: Bogomolnaya LM 

PROVIDER: S-EPMC3809562 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature