Altered dynamics of Candida albicans phagocytosis by macrophages and PMNs when both phagocyte subsets are present.

ABSTRACT:

Unlabelled

An important first line of defense against Candida albicans infections is the killing of fungal cells by professional phagocytes of the innate immune system, such as polymorphonuclear cells (PMNs) and macrophages. In this study, we employed live-cell video microscopy coupled with dynamic image analysis tools to provide insights into the complexity of C. albicans phagocytosis when macrophages and PMNs were incubated with C. albicans alone and when both phagocyte subsets were present. When C. albicans cells were incubated with only one phagocyte subtype, PMNs had a lower overall phagocytic capacity than macrophages, despite engulfing fungal cells at a higher rate once fungal cells were bound to the phagocyte surface. PMNs were more susceptible to C. albicans-mediated killi

SUBMITTER: Rudkin FM 

PROVIDER: S-EPMC3809565 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature