Long-term survival in adults 65 years and older with white matter hyperintensity: association with performance on the digit symbol substitution test.

ABSTRACT:

Objective

White matter hyperintensity (WMH) confers increased mortality risk in patients with cardiovascular diseases. However, little is known about differences in survival times among adults 65 years and older who have WMH and live in the community. To characterize the factors that may reduce mortality risk in the presence of WMH, measures of race, sex, apolipoprotein E4, neuroimaging, and cardiometabolic, physiological, and psychosocial characteristics were examined, with a particular focus on information processing as measured by the Digit Symbol Substitution Test (DSST).

Methods

Cox proportional models were used to estimate mortality risks in a cohort of 3513 adults (74.8 years, 58% women, 84% white) with WMH (0-9 points), DSST (0-90 points), risk factor assessment in 1

SUBMITTER: Rosano C 

PROVIDER: S-EPMC3809761 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature