Ontology highlight
ABSTRACT:
SUBMITTER: Wiget P
PROVIDER: S-EPMC380978 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Wiget Philippe P Shimada Yukiko Y Butty Anne-Christine AC Bi Efrei E Peter Matthias M
The EMBO journal 20040226 5
Receptor-mediated cell polarization via heterotrimeric G-proteins induces cytoskeletal rearrangements in a variety of organisms. In yeast, Far1p is required for orienting cell growth towards the mating partner by linking activated Gbetagamma to the guanine-nucleotide exchange factor (GEF) Cdc24p, which activates the Rho-type GTPase Cdc42p. Here we investigated the role of Far1p in the regulation of Cdc24p in vivo. Using time-lapse microscopy of mating cells and artificial membrane targeting of F ...[more]