NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia.

ABSTRACT: Cachexia is a debilitating condition characterized by extreme skeletal muscle wasting that contributes significantly to morbidity and mortality. Efforts to elucidate the underlying mechanisms of muscle loss have predominantly focused on events intrinsic to the myofiber. In contrast, less regard has been given to potential contributory factors outside the fiber within the muscle microenvironment. In tumor-bearing mice and patients with pancreatic cancer, we found that cachexia was associated with a type of muscle damage resulting in activation of both satellite and nonsatellite muscle progenitor cells. These muscle progenitors committed to a myogenic program, but were inhibited from completing differentiation by an event linked with persistent expression of the self-renewing factor Pax7. Ov

SUBMITTER: He WA 

PROVIDER: S-EPMC3809785 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature