DNA methylation in repetitive elements and post-traumatic stress disorder: a case-control study of US military service members.

ABSTRACT:

Aim

We investigated serum DNA methylation patterns in genomic repetitive elements, LINE-1 and Alu, for post-traumatic stress disorder (PTSD) cases and controls who were US military service members recently deployed to Afghanistan or Iraq.

Methods

Cases (n = 75) had a postdeployment diagnosis of PTSD. Controls (n = 75) were randomly selected service members with no postdeployment PTSD diagnosis. Pre- and post-deployment sera were accessed, DNA was extracted and DNA methylation (percentage 5-methyl cytosine) was quantified via pyrosequencing. Conditional and unconditional logistic regressions were used to compare: cases post- to pre-deployment; controls post- to pre-deployment; cases to controls predeployment; cases to controls postdeployment.

Results

LINE-1 was hyperme

SUBMITTER: Rusiecki JA 

PROVIDER: S-EPMC3809831 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature